When should I take Sleep? Trish February 11, 2020 17:26 Updated Follow About a half an hour before you’d like to go to sleep. Related articles Are there any side effects to Sleep? How quickly will In The Mood work? Will taking Sleep make me groggy? Will Sleep work the first time I use it? How is Rae’s Multivitamin different? Comments 0 comments Please sign in to leave a comment.