When should I take it? Trish September 25, 2019 20:18 Updated Follow About a half an hour before you’d like to go to sleep. Related articles Are there any side effects? How quickly will In The Mood work? Will taking Sleep make me groggy? How is Rae’s Multivitamin different? Will it work the first time I use it? Comments 0 comments Please sign in to leave a comment.