Can I take it every night? Trish September 25, 2019 20:18 Updated Follow Yes. Sleep is safe to take every night. Sleep's natural ingredients should not lead to any kind of dependence. Related articles Will it work the first time I use it? Are there any side effects? Will taking Sleep make me groggy? Will I feel different after taking Daily Cleanse? Can I take In The Mood with my birth control pill? Comments 0 comments Please sign in to leave a comment.